VANCOMYCIN and CLINDAMYCIN

VANCOMYCIN

It also prevents the formation of cell walls.

Mechanism of Action

• It affects the synthesis of cell membranes in organisms that reproduce by interfering with it.
• Numerous gram-positive bacteria, such as group A beta-hemolytic streptococci, staphylococci, pneumococci, enterococci, clostridia, and corynebacteria, are susceptible to this substance. Mycobacteria, fungi, and gram-negative organisms are exceptionally resistant.

Indication

• Infected with MRSA
• False Membrane Colitis
• Endocarditis

Dose

(offered in 500 mg and 750 mg vials)

• Adult
  • Daily doses of 500 mg–2 g in 3–4 divided doses, and
• Children
  • 40 mg/kg (maximum 2 grams) per day

Contraindication

• Hypersensitivity

Side effects

• Nephrotoxicity
• Ototoxicity
• Hypokalemia
• Blue Neck

Nursing Consideration

• Throughout the duration of the drug administration, continuously monitor blood pressure and heart rate.
• Regularly check hematologic tests, kidney and liver function tests, and urinalysis results.
• In individuals older than 60 years, babies, and newborns should have their kidney function monitored.
• Test your hearing. The auditory branch of the eighth cranial nerve may be damaged by drugs.
• Give via intermittent IV infusion for at least 60 minutes, or for no more than 10 mg per minute, whichever is longer.
• It should not be taken without a prescription from a doctor.
• It might make patients allergic. so if it does, let your doctor or pharmacist know.
• Without laboratory proof, the medication shouldn't be taken.
• Give medications continuously
• Keep an eye on your urine output
• Nursing mothers shouldn't take vancomycin because it could pass through their milk.

CLINDAMYCIN 

Mechanism of Action

• It prevents 50s ribosomes in bacteria from synthesizing proteins.

Indication

• Deadly Susceptible Infections, such as
  1. Respiratory
  2. Skin and Soft Tissue
  3. Septicemia
  4. Intraabdominal
  5. Female Pelvic or Genital
  6. Bone and Joint.

Dose

• Adult
  • Serious
    • 150-300mg qid
  • More Severe
    • 300-450mg qid.
• Child
  • Every six hours, take 3 to 6mg/k*g.

Contraindication

• Hypersensitivity

Side Effect

• Nausea
• Diarrhoea
• Vomiting
• Uncomfortable stomach
• Oesophagitis
• Rash
• Jaundice
• Neutropenia
• Thrombophlebitis after IV injection.

Nursing Consideration

• Consider the allergic past-life information.
• Obtain a sample for culture and look at the sensitivity profile.
• Nurses are encouraged to administer this medication before to a meal.
• It is important to periodically have a liver function test done because drugs can either cause or impair liver function.
• Diarrhea and hepatic/renal problems could result from it. If so, the only effective ORS is
• Only a senior physician should be consulted before administering this medication.