NALIDIXIC ACID

Nalidixic acid was a quinolone of the first generation.

Mechanism of action

• By blocking DNA gyrase topoisomerase II, the enzyme that preserves the helical twists in DNA and reverses the super coiling of DNA strands, it prevents the creation of bacterial DNA.

Indication

• Infection of the urinary system brought on by a gram-negative bacteria.
• Intestinal bacterial infection, such as E. coli or Proteus-related diarrhea. Shigella.

Dose

• Adult
  • 500 mg to 1 g daily for 7 to 10 days (pc).
• Child
  • 4 doses of 50 mg/kg per day.

Contraindication

• Children under one year old, people with significant hepatic and renal impairment, quinolone sensitivity, history of convulsions (epilepsy), and epilepsy

Side effect

• Nausea
• Vomiting
• Abdominal pain
• Epigastric distress
• Headache, Dizziness
• Disorientation
• Vertigo
• Convulsions
• Drowsiness
• Rash
• Pruritis
• Photosensitivity
• Jaundice
• Arthralgia
• Visual abnormalities
• Diplopia
• gastro-intestinal upset

Nursing consideration

• It nearly seems immune to microbes. As a result, it is no longer in use.
• Because it may harm the liver, nalidixic acid shouldn't be administered in cases of liver illness.
• Hypothalamic pituitary adrenal axis suppression is more likely when used in youngsters.
• Pregnancy is safe when using it.
• As instructed by medical professionals, the dosage must be finished.
• There is no excuse for skipping the dose.