FRUSEMIDE

Frusemide

To improve urine output excretion, high efficacy loop diuretics are utilized.

Mechanism of action

• It works by preventing Na + /K + / 2C l - transport in the thick ascending loop of Henle nephrons. The loop diuretics increase urine excretion and decrease NaCl reabsorption by blocking this transporter.

Effects of Frusemide:

• significant chloride and sodium diuresis
• Reduce blood volume and edema
• Divalent cation reabsorption [C a ++ times Mg +]

Indication of Frusemide:

• [CCF, ascitis] in an edematous state
• Respiratory edema
• Hypertension
• Furosemide at a high dose combined with intravenous fluids for severe hypercalcemia (in malignancy)

Doses of Frusemide:

• Adults should take furosemide 20–80 mg OD in the morning.
• Up to 20 mg six times per hour has been administered via I/M or I/V in cases of renal insufficiency. 40–80 mg for pulmonary edema. I/V.

Contraindication of Frusemide:

• Patients who are allergic to other sulfonamides may experience allergic cross-reactivity with furosemide, bumetanide, and torsemide, but this seems to be very uncommon.
• Any diuretic should not be used excessively if you have heart failure, borderline renal failure, or hepatic cirrhosis.

Side effects of Frusemide:

• Alkolosis with hypokalemia
• Hypovolemia and a CVS issue
• Ototoxicity
• Reaction to an allergy and others
• Hyperglycemia
• Hyperuricemia